Fosfomycin: an old--new antibiotic

Clin Microbiol Infect. 2012 Jan;18(1):4-7. doi: 10.1111/j.1469-0691.2011.03636.x. Epub 2011 Sep 13.


Fosfomycin is a broad-spectrum antibiotic discovered in Spain in 1969. It has bactericidal activity against a wide range of bacteria, including gram-negative micro-organisms and some gram-positive bacteria, such as staphylococci. Initially fosfomycin was administered parenterally and only to patients with severe infections. Today it is often dispensed as fosfomycin-trometamol, an oral formula recommended in the treatment of urinary tract infections. Fosfomycin-trometamol in a single dose is indicated for the treatment of women with uncomplicated urinary tract infections.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents* / adverse effects
  • Anti-Bacterial Agents* / metabolism
  • Anti-Bacterial Agents* / pharmacokinetics
  • Anti-Bacterial Agents* / pharmacology
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Fosfomycin* / adverse effects
  • Fosfomycin* / metabolism
  • Fosfomycin* / pharmacokinetics
  • Fosfomycin* / pharmacology
  • Humans
  • Urinary Tract Infections / drug therapy*


  • Anti-Bacterial Agents
  • Fosfomycin