Antifungal activity of Ocimum sanctum Linn. (Lamiaceae) on clinically isolated dermatophytic fungi

Asian Pac J Trop Med. 2011 Aug;4(8):654-7. doi: 10.1016/S1995-7645(11)60166-1.

Abstract

Objective: To assess antifungal activity of Ocimum sanctum leaves against dermatophytic fungi.

Methods: Antifungal activity of Ocimum sanctum leaves was measured by 38 A NCCLS method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of Ocimum sanctum leaves were also determined.

Results: Ocimum sanctum leaves possessed antifungal activity against clinically isolated dermatophytes at the concentration of 200 μg/mL. MIC and MFC were high with water fraction (200 μg/mL) against dermatophytic fungi used.

Conclusions: Ocimum sanctum has antifungal activity, and the leaf extracts may be a useful source for dermatophytic infections.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Epidermophyton / drug effects*
  • Epidermophyton / physiology
  • Humans
  • Miconazole / pharmacology
  • Microbial Sensitivity Tests
  • Ocimum / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves / chemistry
  • Solvents
  • Tinea / drug therapy*
  • Tinea / microbiology
  • Water

Substances

  • Antifungal Agents
  • Plant Extracts
  • Solvents
  • Water
  • Miconazole