Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats: possible role of decreased lecithin cholesterol acetyl transferase activity

Asian Pac J Trop Med. 2011 Aug;4(8):658-60. doi: 10.1016/S1995-7645(11)60167-3.

Abstract

Objective: To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats.

Methods: Administration of dexamethasone was given at 10 mg/kg, sc. to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index.

Results: Lemongrass oil (100 and 200 mg/kg, po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg, po. The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase (LCAT) activity.

Conclusions: These results suggested that Lemon gross oil possess significant anti-hyperlipidemic activity.

MeSH terms

  • Animals
  • Atorvastatin
  • Cholesterol / blood
  • Cymbopogon / chemistry*
  • Dexamethasone / adverse effects
  • Heptanoic Acids / pharmacology
  • Hyperlipidemias / blood
  • Hyperlipidemias / chemically induced
  • Hyperlipidemias / drug therapy*
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology*
  • Hypolipidemic Agents / therapeutic use
  • Male
  • Phosphatidylcholine-Sterol O-Acyltransferase / antagonists & inhibitors*
  • Phosphatidylcholine-Sterol O-Acyltransferase / metabolism
  • Phytotherapy / methods*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Plant Oils / therapeutic use
  • Pyrroles / pharmacology
  • Rats
  • Rats, Wistar
  • Terpenes / chemistry
  • Terpenes / pharmacology*
  • Terpenes / therapeutic use
  • Triglycerides / blood

Substances

  • Heptanoic Acids
  • Hypolipidemic Agents
  • Plant Extracts
  • Plant Oils
  • Pyrroles
  • Terpenes
  • Triglycerides
  • lemongrass oil
  • Dexamethasone
  • Cholesterol
  • Atorvastatin
  • Phosphatidylcholine-Sterol O-Acyltransferase