Evaluation of the antipsoriatic activity of Aloe vera leaf extract using a mouse tail model of psoriasis

Phytother Res. 2012 Apr;26(4):617-9. doi: 10.1002/ptr.3589. Epub 2011 Sep 14.

Abstract

Aloe vera gel is used traditionally for the treatment of skin diseases, including psoriasis. An ethanolic extract of the gel was assessed for antipsoriatic activity using a mouse tail model of psoriasis. The extract produced a significant differentiation in the epidermis, as seen from its degree of orthokeratosis (85.07 ± 3.36%) when compared with the negative control (17.30 ± 4.09%). This was equivalent to the effect of the standard positive control, tazarotene (0.1%) gel, which showed a 90.03 ± 2.00% degree of orthokeratosis. The ethanolic extract of Aloe vera leaf gel also produced a significant increase in relative epidermal thickness when compared with the control group, whereas the standard tazarotene showed no change. Taken together, the extract showed an overall antipsoriatic activity of 81.95%, compared with 87.94 for tazarotene, in the mouse tail model for psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aloe / chemistry*
  • Animals
  • Cell Differentiation
  • Dermatologic Agents / therapeutic use
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Epidermis / drug effects
  • Epidermis / pathology
  • Ethanol / chemistry
  • Keratosis / drug therapy
  • Keratosis / pathology
  • Male
  • Mice
  • Nicotinic Acids / therapeutic use*
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Plant Leaves / chemistry*
  • Psoriasis / drug therapy*
  • Psoriasis / pathology
  • Tail / drug effects
  • Tail / pathology

Substances

  • Dermatologic Agents
  • Nicotinic Acids
  • Plant Extracts
  • Ethanol
  • tazarotene