[Morpho-functional peculiarities of autoimmune gastritis in different age groups]

Eksp Klin Gastroenterol. 2011:(5):26-30.
[Article in Russian]

Abstract

In 98 patients with chronic gastritis clinical-morphologic analysis was performed. The analysis included: the examination of gastric biopsy specimens, determination of HP-status by means of a group of methods, determination of antibodies to H+/K+ -ATPase of parietal cells of the gastric wall, IgG-EA-EBV and IgM-NA-EBN antibodies in the blood serum by means of IFA method, pepsinogene I, pepsinogene II, gastrin and antibodies to Hp with the use of Biohit gastric panel, 24-hour monitoring of intragastric pH with the use of Gastroscan-24 machine. Comparison of all parameters was performed in 4 groups: 27 children aged 6-17 with non-autoimmune gastritis and 119 children with gastritis of other etiology, 34 patients aged 18-80 with autoimmune gastritis and 43 patients of the same age group with non-autoimmune gastritis were described. Age-specific peculiarities of autoimmune gastritis in children were determined; and a diagnostic algorithm for its early diagnosis in the latter was developed.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / immunology
  • Aging / pathology*
  • Autoantibodies / blood
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / microbiology
  • Autoimmune Diseases / pathology*
  • Child
  • Chronic Disease
  • Gastric Acid / chemistry
  • Gastric Acidity Determination
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology*
  • Gastritis / immunology
  • Gastritis / microbiology
  • Gastritis / pathology*
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / pathology*
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Middle Aged
  • Pepsinogens / metabolism
  • Young Adult

Substances

  • Autoantibodies
  • Immunoglobulin G
  • Immunoglobulin M
  • Pepsinogens