S100-negative indeterminate cell histiocytosis in an African American child responsive to narrowband ultraviolet B

Pediatr Dermatol. Sep-Oct 2011;28(5):524-7. doi: 10.1111/j.1525-1470.2011.01305.x.

Abstract

Indeterminate cell histiocytosis is a rare cutaneous disease characterized by the presence of dendritic cells that lack Birbeck granules and immunophenotypically shares features of both Langerhans cells and macrophages. We describe a case of a 4-year-old African American boy affected by a disseminated, exclusively mucocutaneous form of indeterminate cell histiocytosis. The eruption was successfully treated with narrowband ultraviolet B. The peculiar negativity of the Langerhans cell marker S100 is also discussed.

Publication types

  • Case Reports

MeSH terms

  • African Americans
  • Child, Preschool
  • Histiocytosis / pathology
  • Histiocytosis / radiotherapy*
  • Humans
  • Langerhans Cells / pathology
  • Langerhans Cells / ultrastructure
  • Male
  • S100 Proteins / analysis
  • Ultraviolet Therapy / methods*

Substances

  • S100 Proteins