Current and future applications of mass spectrometry to the clinical laboratory

Am J Clin Pathol. 2011 Oct;136(4):609-16. doi: 10.1309/AJCPW0TA8OBBNGCK.


Mass spectrometry is an analytic technique with high specificity and a growing presence in laboratory medicine. Various types of mass spectrometers are being used in an increasing number of clinical laboratories around the world, and, as a result, significant improvements in assay performance are occurring rapidly in areas such as toxicology, endocrinology, and biochemical genetics. This review serves as a basic introduction to mass spectrometry, its uses, and associated challenges in the clinical laboratory and ends with a brief discussion of newer methods with the greatest potential for clinical diagnostics.

Publication types

  • Review

MeSH terms

  • Humans
  • Laboratories
  • Mass Spectrometry / methods*
  • Mass Spectrometry / trends*
  • Pathology, Clinical / methods*
  • Pathology, Clinical / trends*