Introduction to statistical methods for analyzing large data sets: gene-set enrichment analysis

Sci Signal. 2011 Sep 6;4(190):tr4. doi: 10.1126/scisignal.2001966.


This Teaching Resource provides lecture notes, slides, and a problem set for a series of lectures introducing the mathematical concepts behind gene-set enrichment analysis (GSEA) and were part of a course entitled "Systems Biology: Biomedical Modeling." GSEA is a statistical functional enrichment analysis commonly applied to identify enrichment of biological functional categories in sets of ranked differentially expressed genes from genome-wide mRNA expression data sets.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Gene Expression Profiling*
  • Gene Expression Regulation*
  • Models, Biological*
  • Systems Biology / education*
  • Systems Biology / methods*
  • Systems Biology / trends