The next level of complexity: post-transcriptional regulation by microRNAs

Kidney Int. 2011 Oct;80(7):692-3. doi: 10.1038/ki.2011.175.


MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that regulate expression of about half of human genes. Canonical miRNA biosynthesis involves two RNase III-type proteins, Drosha and Dicer. A podocyte-specific knockout of Dicer resulted in foot process effacement. In this issue, Zhdanova et al. report on targeting Drosha in a podocyte-specific fashion. Their study demonstrates an essential role of canonical miRNAs in maintaining the fully differentiated podocyte phenotype.

Publication types

  • Comment

MeSH terms

  • Animals
  • Kidney Diseases / genetics*
  • MicroRNAs / genetics*
  • Podocytes / metabolism*
  • Ribonuclease III / genetics*


  • MicroRNAs
  • Drosha protein, mouse
  • Ribonuclease III