Melasma: a comprehensive update: part I

J Am Acad Dermatol. 2011 Oct;65(4):689-697. doi: 10.1016/j.jaad.2010.12.046.


Melasma is a common disorder of hyperpigmentation affecting millions of people worldwide. While it is thought to be triggered or exacerbated by sun exposure and hormones, much remains to be understood about its pathogenesis. A thorough understanding of the etiology of melasma and the research tools available to study this condition are crucial to enhancing management and developing novel targeted therapies of this often frustrating condition.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Melanocytes / radiation effects
  • Melanosis* / etiology
  • Melanosis* / psychology
  • Melanosis* / therapy
  • Pregnancy
  • Pregnancy Complications
  • Quality of Life
  • Sunlight / adverse effects