Longterm experience with low dose weekly methotrexate in rheumatoid arthritis

J Rheumatol Suppl. 1990 May;22:33-8.


Longterm prospective studies (several of greater than 5 years' duration) report sustained efficacy with low dose weekly methotrexate. A "steroid-sparing" effect has been noted with methotrexate in 2 of the studies. Of 230 patients enrolled in prospective studies, only 8% stopped therapy due to toxicity and 3% due to lack of efficacy. Life table analysis projected that 63% of these patients would receive therapy for 6 years. Even though adverse experiences were frequent, serious reactions have been rare in the published studies.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Drug Administration Schedule
  • Humans
  • Life Tables
  • Methotrexate / administration & dosage*
  • Methotrexate / adverse effects
  • Methotrexate / therapeutic use
  • Time Factors


  • Methotrexate