Good's syndrome-associated pure red cell aplasia with myelodysplastic syndrome

Intern Med. 2011;50(18):2011-4. doi: 10.2169/internalmedicine.50.5709. Epub 2011 Sep 15.


We report a case of Good's syndrome-associated pure red cell aplasia (PRCA) with myelodysplastic syndrome (MDS). In this case, effector memory T (T(EM)) cells were expanded in the bone marrow. It remains uncertain whether the development of MDS was caused by the basic marrow defects or radiation therapy. However, since CD8(+) perforin(+) T(EM) cells expanded in the bone marrow, as was previously described for 3 of our patients with thymoma-associated PRCA, it is highly possible that the pathogenic mechanism of PRCA that is accompanied by thymoma is related to the expanded CD8(+) perforin(+) T(EM) cells in this MDS-complicated case.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bone Marrow / pathology
  • Combined Modality Therapy
  • Comorbidity
  • Cyclosporine / therapeutic use
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Immunologic Deficiency Syndromes / therapy
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Myelodysplastic Syndromes / diagnosis
  • Myelodysplastic Syndromes / drug therapy
  • Myelodysplastic Syndromes / etiology*
  • Radiotherapy / adverse effects
  • Red-Cell Aplasia, Pure / diagnosis
  • Red-Cell Aplasia, Pure / drug therapy
  • Red-Cell Aplasia, Pure / etiology*
  • T-Lymphocytes / pathology
  • Thymectomy
  • Thymoma / complications*
  • Thymoma / therapy
  • Thymus Neoplasms / complications*
  • Thymus Neoplasms / therapy


  • Immunosuppressive Agents
  • Cyclosporine