Hemorrhagic transformation in acute cerebellar infarction

Cerebrovasc Dis. 2011;32(4):327-33. doi: 10.1159/000329259. Epub 2011 Sep 15.


Background: Hemorrhagic transformation (HT) is a well-known consequence of acute ischemic stroke, but little is known about HT in cerebellar infarction.

Methods: Patients with acute cerebellar infarction within 48 h of onset were retrospectively recruited. MRI, including diffusion-weighted imaging (DWI) and T(2)*-gradient echo imaging (T(2)*), was performed twice (upon admission and 2 weeks after stroke onset). Infarct diameter and volume were measured by manual tracing on initial DWI. HT was evaluated with follow-up T(2)*, and all patients were divided into two groups according to the presence of HT (HT group and non-HT group). The frequency of HT and the factors associated with HT were investigated.

Results: Ninety-six patients (64 males, median age 74 years, IQR 65-81 years, and National Institute of Health Stroke Scale score 5, IQR 1-14) were enrolled. Forty-two patients (43%) showed HT on follow-up T(2)* (HT group). Infarct diameter and volume were larger in the HT group than in the non-HT group (3.2 vs. 1.6 cm, respectively, p < 0.001, for infarct diameter and 8.0 vs. 1.7 cm(3), respectively, p < 0.001 for infarct volume). Multivariate logistic regression analysis revealed that both infarct diameter >2.7 cm (OR 7.58, 95% CI 2.82-20.4, p < 0.001) and volume >4.5 cm(3) (OR 11.5, 95% CI 3.80-34.8, p < 0.001) were independent factors associated with HT.

Conclusions: Half of the patients with acute cerebellar infarcts had HT on follow-up T(2)*. Initial infarct diameter and volume on DWI were independent factors associated with HT.

MeSH terms

  • Acute Disease
  • Aged
  • Aged, 80 and over
  • Cerebral Hemorrhage / diagnosis
  • Cerebral Hemorrhage / epidemiology*
  • Cerebral Hemorrhage / pathology
  • Cerebral Infarction / complications*
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Follow-Up Studies
  • Hematoma / diagnosis
  • Hematoma / epidemiology*
  • Hematoma / pathology
  • Humans
  • Incidence
  • Male
  • Regression Analysis
  • Retrospective Studies