Staphylococcus aureus biofilms: properties, regulation, and roles in human disease

Virulence. Sep-Oct 2011;2(5):445-59. doi: 10.4161/viru.2.5.17724. Epub 2011 Sep 1.


Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Bacterial Physiological Phenomena*
  • Biofilms / growth & development*
  • Host-Pathogen Interactions
  • Humans
  • Models, Biological
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / immunology
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / pathology
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / growth & development*
  • Staphylococcus aureus / metabolism
  • Staphylococcus aureus / pathogenicity*