[Effect of cepharanthin on radiotherapy induced leukopenia]

Rinsho Hoshasen. 1990 Apr;35(4):471-4.
[Article in Japanese]


Cepharanthin, a kind of alkaloid, has been reported to show a protective effect for leukopenia induced by radiation therapy. In this study, one of three kinds of drugs, Cepharanthin, S-Adchnon (adrenochrome derivative) and Hythiol (L-cysteine), was randomly administered to 94 patients with cancer of the head and neck, the uterine cervix and the lung, during the course of radiotherapy. When Cepharanthin was given, 81.3% of the patients were protected from leukopenia, compared with 51.6% in S-Adchnon and 32.3% in Hythiol. It is suggested that prophylactic use of Cepharanthin may be useful for cancer radiotherapy.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adrenochrome / analogs & derivatives*
  • Adrenochrome / therapeutic use
  • Alkaloids / therapeutic use*
  • Benzylisoquinolines
  • Cysteine / therapeutic use
  • Female
  • Humans
  • Leukopenia / drug therapy*
  • Leukopenia / etiology
  • Neoplasms / radiotherapy*
  • Radiation-Protective Agents / therapeutic use*
  • Radiotherapy / adverse effects*
  • Randomized Controlled Trials as Topic


  • Alkaloids
  • Benzylisoquinolines
  • Radiation-Protective Agents
  • S-Adchnon
  • Adrenochrome
  • cepharanthine
  • Cysteine