Mouse Genomic Variation and Its Effect on Phenotypes and Gene Regulation

Nature. 2011 Sep 14;477(7364):289-94. doi: 10.1038/nature10413.

Abstract

We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that the molecular nature of functional variants and their position relative to genes vary according to the effect size of the locus. These sequences provide a starting point for a new era in the functional analysis of a key model organism.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Animals, Laboratory / genetics
  • Gene Expression Regulation / genetics*
  • Genetic Variation / genetics*
  • Genome / genetics*
  • Genomics
  • Mice / classification
  • Mice / genetics*
  • Mice, Inbred C57BL / genetics
  • Mice, Inbred Strains / genetics*
  • Phenotype*
  • Phylogeny
  • Quantitative Trait Loci / genetics