Functional consequences of developmentally regulated alternative splicing

Nat Rev Genet. 2011 Sep 16;12(10):715-29. doi: 10.1038/nrg3052.


Genome-wide analyses of metazoan transcriptomes have revealed an unexpected level of mRNA diversity that is generated by alternative splicing. Recently, regulatory networks have been identified through which splicing promotes dynamic remodelling of the transcriptome to promote physiological changes, which involve robust and coordinated alternative splicing transitions. The regulation of splicing in yeast, worms, flies and vertebrates affects a variety of biological processes. The functional classes of genes that are regulated by alternative splicing include both those with widespread homeostatic activities and those with cell-type-specific functions. Alternative splicing can drive determinative physiological change or can have a permissive role by providing mRNA variability that is used by other regulatory mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Cell Division / genetics
  • Cell Division / physiology
  • Gene Expression Regulation, Developmental / genetics
  • Gene Expression Regulation, Developmental / physiology*
  • Genes, Developmental / genetics*
  • Humans
  • Models, Biological
  • Organogenesis / genetics
  • Organogenesis / physiology