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, 12 (10), 983-4

The Structural Diversity in α1-antitrypsin Misfolding

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The Structural Diversity in α1-antitrypsin Misfolding

Stephen P Bottomley. EMBO Rep.

Abstract

The structure of α1-antitrypsin polymers, which cause a devastating disease, is vigorously debated. Here, the state of the field is discussed in view of a paradigm-changing structure published in this issue of EMBO reports.

Figures

Figure 1
Figure 1
Structures of native α1-antitrypsin and the known three types of polymer. The reactive centre loop region is highlighted in blue. Antitrypsin is deposited in the Protein Data Bank, ID no. 1QLP. Models of the s4A/s5A swap polymer and carboxy-terminal swap polymer were kindly provided by Professor J. Huntington; the model of the s4A swap polymer was kindly provided by Professor J. Whisstock.

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