Modeling of chromosomal epigenetic silencing processes

Transcription. 2011 Jul;2(4):173-178. doi: 10.4161/trns.2.4.16344.


Silenced genes in eukaryotes are packaged into heterochromatin. In addition to establishing a passive storage site for inactive genes in differentiated cells, silencing can play an active role in promoting cellular differentiation. Here, we describe quantitative modeling of silencing processes.