Aged black garlic extract induces inhibition of gastric cancer cell growth in vitro and in vivo

Mol Med Rep. 2012 Jan;5(1):66-72. doi: 10.3892/mmr.2011.588. Epub 2011 Sep 13.

Abstract

There is mounting evidence that garlic extracts possess significant anticancer actions. However, no studies have been reported on the effects of aged black garlic extracts (ABGE) on gastric cancer in vitro or in vivo. To examine the potential action of ABGE against gastric cancer, the present study evaluated its effect on the inhibition of cell proliferation and induction of apoptosis in SGC-7901 human gastric cancer cells. Additionally, we performed an in vivo study by inoculating the murine foregastric carcinoma cell line in Kunming mice and treating them with various doses of ABGE (0, 200, 400 and 800 mg/kg, intraperitoneally) for 2 weeks. Dose-dependent apoptosis was detected in ABGE-treated cells in in vitro studies. In tumor-bearing mice, significant antitumor effects of ABGE were observed, such as growth inhibition of inoculated tumors. Further investigation of serum superoxide dismutases, glutathione peroxidase, interleukin-2 and the increased indices of spleen and thymus indicated that the anticancer action of ABGE may be partly due to its antioxidant and immunomodulative effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Garlic / chemistry*
  • Glutathione Peroxidase / blood
  • Humans
  • Interleukin-2 / blood
  • Male
  • Mice
  • Plant Extracts / pharmacology*
  • Stomach Neoplasms
  • Superoxide Dismutase / blood
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Interleukin-2
  • Plant Extracts
  • Glutathione Peroxidase
  • Superoxide Dismutase