Nucleic acid-gold nanoparticle conjugates as mimics of microRNA

Small. 2011 Nov 18;7(22):3158-62. doi: 10.1002/smll.201101018. Epub 2011 Sep 16.

Abstract

Novel conjugates of gold nanoparticles (13±1nm) functionalized with synthetic microRNAs can enter cells without the aid of cationic co-carriers and mimic the function of endogenous microRNAs. These conjugates can regulate multiple proteins through interactions with 3′ untranslated region of the target mRNA and control cell behavior. The conjugates are a promising new tool for studying miRNA function and new candidates for miRNA replacement therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • Cell Line, Tumor
  • Cell Movement
  • Cell Proliferation
  • Gold / chemistry*
  • Humans
  • Male
  • Metal Nanoparticles / chemistry*
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Molecular Sequence Data
  • Nucleic Acids / metabolism*
  • Protein Kinase C-epsilon / metabolism

Substances

  • MicroRNAs
  • Nucleic Acids
  • Gold
  • Protein Kinase C-epsilon