Abstract The association of personality traits to personality disorders (PDs) is assumed by many to fit a dimensional model, where PDs emerge at the extremes of personality dimensions. Nevertheless, attempts to demonstrate such an association have been empirically disappointing and conceptually unilluminating. In this article we attempt to extend such models by outlining the neurobehavioural systems that underlie major personality traits, and highlight the evidence that they are subject to experience-dependent modification that can be enduring through effects on genetic expression, mainly through processes known as epigenetics. It is through such processes that risk for personality disorder may be modified by experience at any point in development, but perhaps especially during early critical periods of development. We conclude by presenting a novel multidimensional model of PDs that relies on the concepts developed earlier in the article. Our goal is to provide a guide for research on the psychobiological nature and pharmacological treatment of PDs.