Pharmacological treatments for personality disorders

Int Rev Psychiatry. 2011 Jun;23(3):303-9. doi: 10.3109/09540261.2011.586993.


Abstract This paper presents a systematic review of clinical trials of drugs for patients with personality disorders. Almost all trials have concerned the treatment of borderline personality disorder (BPD). Research yields some evidence for symptomatic improvement with antidepressants, mood stabilizers, and antipsychotics. However, drug treatment does not produce remission of BPD. Routine prescription of these agents for these patients is not evidence-based.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Antimanic Agents / therapeutic use*
  • Antipsychotic Agents / therapeutic use*
  • Borderline Personality Disorder / drug therapy*
  • Borderline Personality Disorder / psychology
  • Humans
  • Personality Disorders / drug therapy
  • Personality Disorders / psychology
  • Remission Induction / methods
  • Treatment Outcome


  • Antidepressive Agents
  • Antimanic Agents
  • Antipsychotic Agents