Reduced microbial attachment by D-amino acid-inhibited AI-2 and EPS production

Water Res. 2011 Nov 1;45(17):5796-804. doi: 10.1016/j.watres.2011.08.061. Epub 2011 Sep 3.

Abstract

This study investigated the effect of D-tyrosine on microbial attachment to hydrophilic glass and hydrophobic polypropylene surfaces. Results showed that D-tyrosine did not influence microbial growth, ATP and substrate utilization, but significantly inhibited the synthesis of autoinducer-2 (AI-2), eDNA and extracellular polysaccharides and proteins, and subsequently reduced microbial attachment onto glass and polypropylene surfaces was observed. It was shown that D-amino acid would be a non-toxic agent for control of microbial attachment.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Bacteria / drug effects*
  • Bacteria / growth & development
  • Bacterial Adhesion / drug effects*
  • Bacterial Proteins / metabolism
  • Biopolymers / biosynthesis*
  • Carbon / analysis
  • Chromatography, Gel
  • DNA, Bacterial / metabolism
  • Extracellular Space
  • Homoserine / analogs & derivatives*
  • Homoserine / biosynthesis
  • Lactones
  • Microscopy, Confocal
  • Polysaccharides, Bacterial / metabolism
  • Tyrosine / pharmacology*

Substances

  • Bacterial Proteins
  • Biopolymers
  • DNA, Bacterial
  • Lactones
  • N-octanoylhomoserine lactone
  • Polysaccharides, Bacterial
  • Tyrosine
  • Homoserine
  • Carbon
  • Adenosine Triphosphate