[Drugs in pregnancy: study in the EFEMERIS database (2004 to 2008)]

Gynecol Obstet Fertil. 2011 Oct;39(10):554-8. doi: 10.1016/j.gyobfe.2011.07.044. Epub 2011 Sep 15.
[Article in French]


Objectives: To analyze the evolution of drug prescriptions during pregnancy from 2004 to 2008 in Haute-Garonne (France) and the impact of recommendations concerning drugs in pregnancy sent by French health authorities (AFSSAPS) and French college of gynaecologists and obstetricians to health professionals during the period.

Patients and methods: This descriptive study of reimbursed drug prescriptions during pregnancy concerns women included in the EFEMERIS database who have given birth from July 1st, 2004 to June 30th, 2008. The health insurance service records of Haute-Garonne were used.

Results: Taking into account 2 subsequent delistings of drugs for reimbursement during the period, we observed a significant increase of reimbursed drug prescriptions dispensed to pregnant women (8.7 different substances for women who have given birth in 2004 and 9.4 in 2008). Vitamins, immunserums, immunoglobulins and homeopathy prescriptions have especially increased. Paracetamol, iron, folic acid and phloroglucinol were the most prescribed drugs during all the periods.

Discussion and conclusion: Since 2004, EFEMERIS represents a monitoring centre for the prescription of reimbursed drugs to pregnant women. This analysis allowed to exhibit trends in prescription patterns. Most of the alerts or recommendations had a positive but limited impact.

Publication types

  • English Abstract

MeSH terms

  • Acetaminophen / administration & dosage
  • Databases, Factual / statistics & numerical data
  • Drug Prescriptions / statistics & numerical data*
  • Female
  • Folic Acid / administration & dosage
  • Humans
  • Immune Sera / administration & dosage
  • Immunoglobulins / administration & dosage
  • Insurance, Health / statistics & numerical data
  • Iron / administration & dosage
  • Materia Medica / administration & dosage
  • Phloroglucinol / administration & dosage
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Vitamins / administration & dosage


  • Immune Sera
  • Immunoglobulins
  • Materia Medica
  • Vitamins
  • Acetaminophen
  • Folic Acid
  • Phloroglucinol
  • Iron