Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis

Jpn J Clin Oncol. 2011 Oct;41(10):1233-7. doi: 10.1093/jjco/hyr119. Epub 2011 Sep 16.


Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Brain-Derived Neurotrophic Factor / blood*
  • Case-Control Studies
  • Depressive Disorder, Major / blood*
  • Depressive Disorder, Major / diagnosis
  • Female
  • Humans
  • Japan
  • Life Change Events*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / psychology*
  • Male
  • Matched-Pair Analysis
  • Sex Factors


  • Biomarkers
  • Brain-Derived Neurotrophic Factor