Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

Nat Med. 2011 Sep 18;17(10):1315-9. doi: 10.1038/nm.2472.


The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.

MeSH terms

  • Aged
  • Diagnostic Imaging / methods*
  • Female
  • Fluorescein-5-isothiocyanate / chemistry
  • Folate Receptor 1 / metabolism*
  • Humans
  • Microscopy, Fluorescence / methods*
  • Middle Aged
  • Molecular Structure
  • Monitoring, Intraoperative / methods*
  • Ovarian Neoplasms / pathology*


  • Folate Receptor 1
  • Fluorescein-5-isothiocyanate