Microsomal prostaglandin e synthase-1 in rheumatic diseases

Front Pharmacol. 2011 Jan 20;1:146. doi: 10.3389/fphar.2010.00146. eCollection 2010.


Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding of mPGES-1 in rheumatoid arthritis, osteoarthritis, and inflammatory myopathies. Novel findings regarding regulation of mPGES-1 cell expression as well as enzyme inhibitors are also summarized.

Keywords: inflammatory myositis; inhibitors; osteoarthritis; prostaglandin E synthase; rheumatoid arthritis.