Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation

Arch Surg. 2011 Sep;146(9):1041-7. doi: 10.1001/archsurg.2011.216.


Background: Gastroesophageal reflux disease (GERD) is common in patients with end-stage lung disease (ESLD). GERD may cause obliterative bronchiolitis after lung transplantation (LTx), represented by a decline in forced expiratory volume in 1 second (FEV(1)).

Objectives: To identify the patterns of reflux in patients with ESLD and to determine whether antireflux surgery (ARS) positively impacts lung function.

Design: Retrospective review of prospectively collected data.

Setting: Tertiary care university hospital.

Patients: Forty-three patients with ESLD and documented GERD (pre-LTx, 19; post-LTx, 24).

Interventions: Antireflux surgery.

Main outcome measures: Reflux patterns including laryngopharyngeal reflux as measured by esophageal impedance, and FEV(1), and episodes of pneumonia and acute rejection before and after ARS.

Results: Before ARS, 19 of 43 patients (44%) were minimally symptomatic or asymptomatic. Laryngopharyngeal reflux events, which occurred primarily in the upright position, were common in post-LTx (56%) and pre-LTx (31%) patients. At 1 year after ARS, FEV(1) significantly improved in 91% of the post-LTx patients (P < .01) and 85% of the pre-LTx patients (P = .02). Of patients with pre-ARS declining FEV(1), 92% of post-LTx and 88% of pre-LTx patients had a reversal of this trend. Episodes of pneumonia and acute rejection were significantly reduced in post-LTx patients (P = .03) or stablilized in pre-LTx patients (P = .09).

Conclusions: There should be a low threshold for performing objective esophageal testing including esophageal impedance because GERD may be occult and ARS may improve or prolong allograft and native lung function.

MeSH terms

  • Adult
  • Aged
  • Bronchiolitis Obliterans / epidemiology*
  • Bronchiolitis Obliterans / etiology
  • Bronchiolitis Obliterans / physiopathology
  • Comorbidity
  • Cystic Fibrosis / epidemiology
  • Female
  • Forced Expiratory Volume
  • Gastroesophageal Reflux / complications
  • Gastroesophageal Reflux / epidemiology*
  • Gastroesophageal Reflux / surgery*
  • Humans
  • Lung Diseases / epidemiology
  • Lung Transplantation*
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive / epidemiology
  • Pulmonary Fibrosis / epidemiology
  • Respiratory Function Tests
  • Retrospective Studies
  • Scleroderma, Systemic / epidemiology