On the origin of the triplet puzzle of homologies in receptor heteromers: immunoglobulin triplets in different types of receptors

J Mol Neurosci. 2012 Mar;46(3):616-21. doi: 10.1007/s12031-011-9649-5. Epub 2011 Sep 20.

Abstract

Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may "guide-and-clasp" receptor-receptor interactions playing a role, e.g., in neuroinflammation disorders.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Epitopes / chemistry
  • Epitopes / immunology
  • Humans
  • Immunoglobulin G / chemistry*
  • Immunoglobulin Heavy Chains / chemistry
  • Immunoglobulin Light Chains / chemistry
  • Immunoglobulin M / chemistry*
  • Models, Chemical*
  • Neurogenic Inflammation / immunology
  • Neurogenic Inflammation / metabolism
  • Neuroimmunomodulation / genetics
  • Neuroimmunomodulation / immunology
  • Protein Interaction Domains and Motifs / immunology
  • Protein Multimerization / immunology
  • Receptors, GABA-B / chemistry
  • Sequence Homology, Amino Acid

Substances

  • Epitopes
  • Immunoglobulin G
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Light Chains
  • Immunoglobulin M
  • Receptors, GABA-B