Silver-mediated trifluoromethylation of arenes using TMSCF3

Org Lett. 2011 Oct 21;13(20):5464-7. doi: 10.1021/ol202174a. Epub 2011 Sep 20.

Abstract

The silver-mediated C-H trifluoromethylation of aromatic substrates using TMSCF(3) is described. The development, optimization, and scope of these transformations are reported. AgCF(3) intermediates are proposed.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Benzene Derivatives / chemical synthesis*
  • Benzene Derivatives / chemistry
  • Catalysis
  • Hydrocarbons, Fluorinated / chemistry*
  • Mesylates / chemistry*
  • Molecular Structure
  • Palladium
  • Silanes / chemistry*

Substances

  • Benzene Derivatives
  • Hydrocarbons, Fluorinated
  • Mesylates
  • Silanes
  • Palladium
  • trimethyl(trifluoromethyl)silane
  • trifluoromethanesulfonic acid