Abstract
Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and recent x-ray crystallography of the GA-GID1 complex has given insights into how GID1 recognizes GA. Analyses of the GA signaling pathway in several plant species further suggest that the GID1-mediated GA signaling pathway emerged in the vascular plant lineage and since then regulation of GA recognition specificity seems to have been fine tuned to strictly regulate the on-off GA signal.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Arabidopsis Proteins / chemistry
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Arabidopsis Proteins / genetics
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Arabidopsis Proteins / metabolism
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Evolution, Molecular
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F-Box Proteins / chemistry
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F-Box Proteins / genetics
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F-Box Proteins / metabolism
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Genes, Plant / physiology
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Gibberellins / metabolism*
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Models, Biological
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Models, Molecular
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Protein Binding / genetics
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Protein Interaction Domains and Motifs / genetics*
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Protein Interaction Domains and Motifs / physiology
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / genetics*
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Receptors, Cell Surface / metabolism
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Sterol Esterase / chemistry*
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Sterol Esterase / genetics*
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Sterol Esterase / metabolism
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Substrate Specificity / genetics
Substances
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Arabidopsis Proteins
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F-Box Proteins
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GID1a protein, Arabidopsis
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Gibberellins
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Receptors, Cell Surface
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Sterol Esterase