Scoring the proliferative activity of haemangioma of infancy: the Haemangioma Activity Score (HAS)

Clin Exp Dermatol. 2011 Oct;36(7):715-23. doi: 10.1111/j.1365-2230.2011.04080.x. Epub 2011 Jun 10.


Background: Haemangioma of infancy (HOI) is the most frequently occurring benign tumour of infancy. A good, reliable and objective scoring system for haemangioma activity is not yet available.

Aim: We have developed a simple system called the Haemangioma Activity Score (HAS) for scoring the (disease) proliferative activity of haemangiomas. The current study was undertaken to validate this system.

Methods: We validated the HAS in a comparative study of photographs taken during consultations from 2000 until 2008 (n = 78). Agreement between three observers was assessed at two different time points (t(0) and t(1)) with a minimum interval of 6 months between them, using interclass correlation coefficients (ICC).

Results: Agreement between observers was good. The average ICC of the HAS at t(0) and t(1) was 0.72 and 0.76, respectively. The average ICC of the HAS for the changes from baseline (HAS at t(0) minus HAS at t(1) ) was 0.69.

Conclusions: We conclude that the HAS is a good system for scoring the proliferative activity of haemangiomas, and believe it to be useful in future investigations. The number of studies comparing different therapies for treating haemangiomas is steadily increasing, and the HAS (before and after treatment) may provide a valuable scoring system for evaluating such therapies.

Publication types

  • Validation Study

MeSH terms

  • Disease Progression
  • Female
  • Hemangioma / pathology*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Observer Variation
  • Pilot Projects
  • Reproducibility of Results
  • Severity of Illness Index