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Comparative Study
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Stability of the Factorial Structure of Metabolic Syndrome From Childhood to Adolescence: A 6-year Follow-Up Study

Comparative Study

Stability of the Factorial Structure of Metabolic Syndrome From Childhood to Adolescence: A 6-year Follow-Up Study

Vicente Martínez-Vizcaino et al. Cardiovasc Diabetol.


Background: Metabolic syndrome (MS) is a clustering of cardiometabolic risk factors that is considered a predictor of cardiovascular disease, type 2 diabetes and mortality. There is no consistent evidence on whether the MS construct works in the same way in different populations and at different stages in life.

Methods: We used confirmatory factor analysis to examine if a single-factor-model including waist circumference, triglycerides/HDL-c, insulin and mean arterial pressure underlies metabolic syndrome from the childhood to adolescence in a 6-years follow-up study in 174 Swedish and 460 Estonian children aged 9 years at baseline. Indeed, we analyze the tracking of a previously validated MS index over this 6-years period.

Results: The estimates of goodness-of-fit for the single-factor-model underlying MS were acceptable both in children and adolescents. The construct stability of a new model including the differences from baseline to the end of the follow-up in the components of the proposed model displayed good fit indexes for the change, supporting the hypothesis of a single factor underlying MS component trends.

Conclusions: A single-factor-model underlying MS is stable across the puberty in both Estonian and Swedish young people. The MS index tracks acceptably from childhood to adolescence.


Figure 1
Figure 1
Study design and aims of the present study.
Figure 2
Figure 2
Factor loading and goodness-of-fit indexes of a single factor models for the metabolic syndrome. Total sample: n = 2064; χ2 = 10.87, df = 2, p = 0.004; CFI = 0.97; and SRMR = 0.019. Estonian sample: n = 1158; χ2 = 3.70, df = 2, p = 0.159; CFI = 0.99; and SRMR = 0.016. Swedish sample: n = 906; χ2 = 37.4, df = 2, p = 0.001; CFI = 0.96; and SRMR = 0.051. MAP: mean arterial pressure.
Figure 3
Figure 3
Goodness of fit and stability of the MetS factorial structure (A) at baseline, (B) after 6 yr follow up, and (C) including as components the change in the variables from 1998 to 2005. A: n = 634; χ2 = 5.6, df = 2, p = 0.06; CFI = 0.98; and SRMR = 0.026. B: n = 634; χ2 = 6.7, df = 2, p = 0.03; CFI = 0.97; and SRMR = 0.027. C: n = 634 χ2 = 0.32, df = 2, p = 0.85; CFI = 0.1; and SRMR = 0.006. MAP: mean arterial pressure.

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