Abstract
Metronidazole-resistant vaginal trichomoniasis remains a major therapeutic challenge. Two women with symptomatic metronidazole-resistant trichomoniasis had multiple unsuccessful courses of therapy with a broad array of medications. Both patients finally responded to combination treatment with intravaginal paromomycin cream and high-dose oral tinidazole.
MeSH terms
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Administration, Intravaginal
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Administration, Oral
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Adult
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Antiprotozoal Agents / pharmacology
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Antiprotozoal Agents / therapeutic use
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Antitrichomonal Agents / administration & dosage
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Antitrichomonal Agents / therapeutic use*
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Combined Modality Therapy
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Drug Resistance, Multiple
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Female
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Humans
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Male
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Metronidazole / pharmacology
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Metronidazole / therapeutic use
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Middle Aged
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Paromomycin / administration & dosage
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Paromomycin / therapeutic use*
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Sexual Partners
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Tinidazole / administration & dosage
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Tinidazole / therapeutic use*
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Treatment Outcome
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Trichomonas Vaginitis / diagnosis
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Trichomonas Vaginitis / drug therapy*
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Trichomonas Vaginitis / parasitology
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Trichomonas vaginalis / drug effects*
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Trichomonas vaginalis / isolation & purification
Substances
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Antiprotozoal Agents
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Antitrichomonal Agents
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Tinidazole
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Metronidazole
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Paromomycin