Resistant trichomoniasis: successful treatment with combination therapy

Sex Transm Dis. 2011 Oct;38(10):962-3. doi: 10.1097/OLQ.0b013e31822037e4.

Abstract

Metronidazole-resistant vaginal trichomoniasis remains a major therapeutic challenge. Two women with symptomatic metronidazole-resistant trichomoniasis had multiple unsuccessful courses of therapy with a broad array of medications. Both patients finally responded to combination treatment with intravaginal paromomycin cream and high-dose oral tinidazole.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravaginal
  • Administration, Oral
  • Adult
  • Antiprotozoal Agents / pharmacology
  • Antiprotozoal Agents / therapeutic use
  • Antitrichomonal Agents / administration & dosage
  • Antitrichomonal Agents / therapeutic use*
  • Combined Modality Therapy
  • Drug Resistance, Multiple
  • Female
  • Humans
  • Male
  • Metronidazole / pharmacology
  • Metronidazole / therapeutic use
  • Middle Aged
  • Paromomycin / administration & dosage
  • Paromomycin / therapeutic use*
  • Sexual Partners
  • Tinidazole / administration & dosage
  • Tinidazole / therapeutic use*
  • Treatment Outcome
  • Trichomonas Vaginitis / diagnosis
  • Trichomonas Vaginitis / drug therapy*
  • Trichomonas Vaginitis / parasitology
  • Trichomonas vaginalis / drug effects*
  • Trichomonas vaginalis / isolation & purification

Substances

  • Antiprotozoal Agents
  • Antitrichomonal Agents
  • Tinidazole
  • Metronidazole
  • Paromomycin