Malignant pirates of the immune system

Nat Immunol. 2011 Sep 20;12(10):933-40. doi: 10.1038/ni.2094.

Abstract

At great human cost, cancer is the largest genetic experiment ever conducted. This review highlights how lymphoid malignancies have genetically perverted normal immune signaling and regulatory mechanisms for their selfish oncogenic goals of unlimited proliferation, perpetual survival and evasion of the immune response.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • CD79 Antigens / genetics
  • DNA-Binding Proteins / physiology
  • Humans
  • Immune System / physiology*
  • Interferon Regulatory Factors / physiology
  • Janus Kinase 2 / physiology
  • Lymphoma / immunology*
  • Myeloid Differentiation Factor 88 / genetics
  • Oncogenes
  • Proto-Oncogene Proteins c-bcl-6
  • Signal Transduction
  • Transcription Factors / physiology

Substances

  • BCL6 protein, human
  • CD79 Antigens
  • DNA-Binding Proteins
  • Interferon Regulatory Factors
  • Myeloid Differentiation Factor 88
  • Proto-Oncogene Proteins c-bcl-6
  • Transcription Factors
  • interferon regulatory factor-4
  • JAK2 protein, human
  • Janus Kinase 2