Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging

Opt Express. 2011 Aug 29;19(18):17030-9. doi: 10.1364/OE.19.017030.


Indocyanine green-loaded mesoporous silica-coated gold nanorods (ICG-loaded Au@SiO2) were prepared for the dual capability of X-ray computed tomography (CT) and fluorescence imaging. X-ray CT scanning showed that ICG-loaded Au@SiO2 could provide significant contrast enhancement; Near-infrared fluorescence generated by the nanomaterial was present up to 12 h post intratumoral injection, thus enabling ICG-loaded Au@SiO2 to be used as a promising dual mode imaging contrast agent. Multiplexed images can be more easily obtained with this novel type of multimodal nanostructure compared with traditional contrast agents. The dual mode imaging probe has great potential for use in applications such as cancer targeting, molecular imaging in combination with radiotherapy, and photothermolysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Contrast Media*
  • Diagnostic Imaging / methods
  • Female
  • Fluorescence
  • Fluorescent Dyes
  • Gold
  • Indocyanine Green*
  • Metal Nanoparticles*
  • Mice
  • Mice, Nude
  • Nanocomposites
  • Nanotubes
  • Silicon Dioxide
  • Spectroscopy, Near-Infrared / methods*
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / diagnostic imaging
  • Tomography, X-Ray Computed / methods*


  • Contrast Media
  • Fluorescent Dyes
  • Gold
  • Silicon Dioxide
  • Indocyanine Green