Effects of daily consumption of probiotic yoghurt on inflammatory factors in pregnant women: a randomized controlled trial

Pak J Biol Sci. 2011 Apr 15;14(8):476-82. doi: 10.3923/pjbs.2011.476.482.


Previous studies have shown that inflammatory factors increases in pregnancy and is associated with several complications of pregnancy. The aim of this study was to assess effects of daily consumption of probiotic yoghurt on inflammatory factors in pregnant women. In a randomized clinical trial, seventy primigravid (the first pregnancy) and singleton pregnant women aged 18-30 years were assigned to two groups. Subjects consumed daily 200 g probiotic yoghurt containing Lactobacillus acidophilus La5 and Bifidobacterium animalis BB12 (10(7) CFU g(-1) for each) or 200 g conventional yoghurt for 9 weeks. Fasting blood samples were collected at baseline (28 weeks of gestation) and after intervention (37 weeks of gestation). Inflammatory factors, hs-CRP and TNF-alpha, were measured by Enzyme-linked Immunosorbent Assay (ELISA). Independent t-test was used to compare the two groups after intervention and paired-sample t-test compared variables before and after treatment. The results showed that the probiotic yogurt brought about a decrease in the serum hs-CRP level, from 10.44 +/- 1.56 to 7.44 +/- 1.03 microg mL(-1) (p = 0.041). There was no significant change in the conventional yogurt group in the serum hs-CRP level (12.55 +/- 1.57 to 14.51 +/- 1.62 microg mL(-1), p = 0.202). The probiotic yogurt had no effect on TNF-alpha (from 73.75 +/- 6.59 to 77.91 +/- 5.61 pg mL(-1), p = 0.633). Serum TNF-alpha did not change in the conventional yogurt group (p = 0.134). In conclusion probiotic yogurt significantly decreased hs-CRP in pregnant women but had no effect on TNF-alpha.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Bifidobacterium
  • C-Reactive Protein / metabolism
  • Female
  • Humans
  • Inflammation Mediators / blood*
  • Lactobacillus acidophilus
  • Pre-Eclampsia / blood
  • Pre-Eclampsia / prevention & control
  • Pregnancy
  • Probiotics / administration & dosage*
  • Prospective Studies
  • Single-Blind Method
  • Tumor Necrosis Factor-alpha / blood
  • Yogurt* / microbiology
  • Young Adult


  • Inflammation Mediators
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein