Dimethyl sulfoxide-sodium bicarbonate infusion for palliative care and pain relief in patients with metastatic prostate cancer

J Pain Palliat Care Pharmacother. 2011;25(4):350-5. doi: 10.3109/15360288.2011.606294. Epub 2011 Sep 21.


Prostate cancer (adenocarcinoma of the prostate) is the most widespread cancer in men. It causes significant suffering and mortality due to metastatic disease. The main therapy for metastatic prostate cancer (MPC) includes androgen manipulation, chemotherapy, and radiotherapy and/or radioisotopes. However, these therapeutic approaches are considered palliative at this stage, and their significant side effects can cause further decline in patients' quality of life and increase non-cancer-related morbidity/mortality. In this study, the authors have used the infusion of dimethyl sulfoxide-sodium bicarbonate (DMSO-SB) to treat 18 patients with MPC. The 90-day follow-up of the patients having undergone the proposed therapeutic regimen showed significant improvement in clinical symptoms, blood and biochemistry tests, and quality of life. There were no major side effects from the treatment. In searching for new and better methods for palliative treatment and pain relief, this study strongly suggested therapy with DMSO-SB infusions could provide a rational alternative to conventional treatment for patients with MPC.

MeSH terms

  • Adenocarcinoma
  • Aged
  • Dimethyl Sulfoxide / standards
  • Dimethyl Sulfoxide / therapeutic use*
  • Drug Combinations
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Pain / drug therapy*
  • Pain / etiology
  • Pain Measurement
  • Palliative Care / methods*
  • Prostatic Neoplasms / complications
  • Prostatic Neoplasms / pathology
  • Quality of Life
  • Sodium Bicarbonate / standards
  • Sodium Bicarbonate / therapeutic use*
  • Treatment Outcome
  • Vietnam


  • Drug Combinations
  • Sodium Bicarbonate
  • Dimethyl Sulfoxide