Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain

Nature. 1979 Apr 19;278(5706):740-1. doi: 10.1038/278740a0.
No abstract available

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analgesia
  • Clinical Trials as Topic
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Endorphins / physiology
  • Female
  • Humans
  • Male
  • Naloxone / pharmacology*
  • Pain / physiopathology*
  • Postoperative Period
  • Receptors, Opioid / drug effects
  • Time Factors

Substances

  • Endorphins
  • Receptors, Opioid
  • Naloxone