Effects of gadoxetic acid on liver elasticity measurement by using magnetic resonance elastography

Magn Reson Imaging. 2012 Jan;30(1):128-32. doi: 10.1016/j.mri.2011.08.005. Epub 2011 Sep 19.


The purpose of this study was to evaluate the effect of gadoxetic acid (Gd-EOB-DTPA) on measurements of liver stiffness by using magnetic resonance elastography (MRE). In this study, 104 consecutive patients (mean age, 67.7±9.4 years) underwent MRE using a 1.5-T MR scanner equipped with a cylindrical passive driver that was placed across the right chest wall for delivering vibrations. Axial gradient-echo images, which were automatically converted to elastograms that represented stiffness (kPa), were acquired using a continuous sinusoidal vibration of 60 Hz. Two raters independently placed a region of interest on the right lobe of the liver on the elastograms obtained before and after Gd-EOB-DTPA was administered. Liver stiffness was measured using these two elastograms and compared using a paired t test and correlation analysis. No significant difference was observed in liver stiffness before and after Gd-EOB-DTPA was administered (Rater 1, P=.1200; Rater 2, P=.3585). The correlation coefficients were 0.986 (Rater 1) and 0.984 (Rater 2), indicating excellent correlation between the stiffness values before and after Gd-EOB-DTPA was administered. Liver stiffness measured by MRE did not differ before and after Gd-EOB-DTPA was administered.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Contrast Media / administration & dosage
  • Dose-Response Relationship, Drug
  • Elastic Modulus / drug effects
  • Elasticity Imaging Techniques / methods*
  • End Stage Liver Disease / pathology
  • End Stage Liver Disease / physiopathology*
  • Female
  • Gadolinium DTPA / administration & dosage*
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Liver / drug effects
  • Liver / physiopathology*
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Sensitivity and Specificity


  • Contrast Media
  • gadolinium ethoxybenzyl DTPA
  • Gadolinium DTPA