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. 2011 Dec;133(1-3):125-32.
doi: 10.1016/j.schres.2011.08.013. Epub 2011 Sep 19.

Advanced Paternal Age and Parental History of Schizophrenia

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Free PMC article

Advanced Paternal Age and Parental History of Schizophrenia

Brian Miller et al. Schizophr Res. .
Free PMC article

Abstract

Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP.

Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort.

Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95% confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA.

Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the "de novo mutation" hypothesis.

Conflict of interest statement

Conflict of Interest

Dr. Miller received grant support from the University of Oulu and Oy H. Lundbeck.

Dr. Suvisaari received grant support from the Academy of Finland.

Dr. Miettunen received grant support from the Academy of Finland (125853) and an Independent Investigator award from NARSAD: The Brain and Behavior Research Fund.

Dr. Järvelin has nothing to disclose.

Dr. Haukka has been in research collaboration with Janssen-Cilag, Novo Nordisk, and Eli Lilly and has been a member of the expert advisory group for Astellas.

Dr. Tanskanen has nothing to disclose.

Dr. Lönnqvist has nothing to disclose.

Dr. Isohanni received consulting and/or speaking fees from AstraZeneca and Janssen-Cilag.

Dr. Kirkpatrick received consulting and/or speaking fees from Pfizer, Organon, AstraZeneca, Wyeth, Bristol Myers Squibb, Solvay, Sunovion, Boehringer Ingelheim, Abbott, and Cephalon.

Figures

Figure 1
Figure 1
Association Between Paternal Age and Parental History Group in the Finnish NAP Cohort
Figure 2
Figure 2
Association Between Paternal Age and Parental History Group in the NFBC 1966

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