Abstract
Healthy midlife children of a parent with Alzheimer's disease ([AD] N = 23; 9 male) participated in neuropsychological testing, and magnetic resonance imaging (MRI) of brain volumetrics were obtained. In all, 35% of the sample were apolipoprotein E (ApoE)-e4 positive (n = 8; 5 male). The ApoE-e4 group exhibited significantly slower performances on an executive function and processing speed measure and had less white matter volume than the non-ApoE-e4 group. Lesser white matter volume was significantly correlated with slower processing speed. Processing speed and changes in white matter volume might be indicators of preclinical decline in AD.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Alzheimer Disease* / epidemiology
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Alzheimer Disease* / genetics
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Alzheimer Disease* / pathology
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Apolipoprotein E4 / genetics*
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology
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Child of Impaired Parents / statistics & numerical data*
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Cognition / physiology*
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Female
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Genetic Predisposition to Disease / epidemiology
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Genetic Predisposition to Disease / genetics
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Hippocampus / pathology
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Hippocampus / physiopathology
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Humans
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Hydrocortisone / metabolism
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Nerve Fibers, Myelinated / pathology*
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Neuropsychological Tests
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Predictive Value of Tests
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Prevalence
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Risk Factors
Substances
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Apolipoprotein E4
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Hydrocortisone