Effect of Fluoxetine on Some Cognitive Functions of Patients of Depression

Indian J Psychol Med. 2009 Jan;31(1):24-9. doi: 10.4103/0253-7176.53311.


Background: This study was carried out to evaluate the effect of long-term administration of a commonly prescribed antidepressant, fluoxetine from different group on memory and psychomotor functions in patients of various psychiatric disorders using a battery of simple tests that can be conveniently applied to the Indian population.

Materials and methods: Memory was evaluated using the PGI memory scale and psychomotor functions were evaluated using six letter cancellation test. Statistical analysis was carried out using Wilcoxon signed-rank test.

Results and conclusion: The results of the study reveal that there was significant improvement in some cognitive function. Cognitive functions are improved at first follow-up and they improved continuously up to last follow-up that is at one month. It is observed that there was improvement in the primary disease. So, final score of the cognitive parameters is because of the resultant activity of direct drug action and improvement in the underlying disease.

Keywords: Antidepressants; PGI memory scale; fluoxetine.