A review of the health consequences of the vitamin D deficiency pandemic

J Neurol Sci. 2011 Dec 15;311(1-2):15-8. doi: 10.1016/j.jns.2011.08.046. Epub 2011 Sep 22.


Rickets, osteomalacia, osteoporosis and myopathy are among the better known consequences of a low to very low vitamin D status. Over the past several years various predominantly epidemiological and prospective cohort studies have found associations between low vitamin D levels and various extraskeletal conditions. These findings may particularly become important over the next years since large proportions of the population have low vitamin D levels. Increasing incidence rates of obesity, adverse life-style factors and active avoidance of sunlight seem to decrease average population mean vitamin D levels further. This article gives a brief overview of known and also less well-established potential detrimental effects of a low vitamin D status.

Publication types

  • Review

MeSH terms

  • Cohort Studies
  • Comorbidity / trends
  • Humans
  • Muscular Diseases / drug therapy
  • Muscular Diseases / epidemiology
  • Muscular Diseases / prevention & control
  • Neoplasms / drug therapy
  • Neoplasms / epidemiology
  • Neoplasms / prevention & control
  • Osteoporosis / drug therapy
  • Osteoporosis / epidemiology
  • Osteoporosis / prevention & control
  • Pandemics* / prevention & control
  • Prospective Studies
  • Vitamin D Deficiency / drug therapy
  • Vitamin D Deficiency / epidemiology*
  • Vitamin D Deficiency / prevention & control