Abstract
Spinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of CAG triplets in the androgen receptor. Because the length of CAG repeat is inversely related with androgen receptor function, patients with a longer CAG repeat are expected to have a lower incidence of prostate cancer. Here, we report an extremely rare case of high-stage prostate cancer in a patient with spinal and bulbar muscular atrophy, which responded to maximal androgen blockade therapy.
MeSH terms
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Androgen Antagonists / therapeutic use*
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Bulbo-Spinal Atrophy, X-Linked
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Flutamide / therapeutic use*
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Gonadotropin-Releasing Hormone / agonists
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Humans
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Leuprolide / therapeutic use
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Male
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Middle Aged
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Neoplasm Grading
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Prostatic Neoplasms / drug therapy
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Prostatic Neoplasms / genetics
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Prostatic Neoplasms / pathology*
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Receptors, Androgen / genetics
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Trinucleotide Repeats
Substances
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AR protein, human
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Androgen Antagonists
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Receptors, Androgen
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Gonadotropin-Releasing Hormone
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Flutamide
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Leuprolide