Influence of thymopentin on antibody response, and monocyte and T cell function in hemodialysis patients who fail to respond to hepatitis B vaccination

Nephron. 1990;55(2):136-40. doi: 10.1159/000185941.

Abstract

We investigated the influence of thymopentin as an adjuvant for hepatitis B vaccination on in vitro monocyte and T cell function and in vivo antibody response in a prospective, placebo-controlled double-blind trial in 20 low- and nonresponders to hepatitis B vaccination on chronic hemodialysis. 50 mg thymopentin was given subcutaneously twice per week for 3 weeks, followed by 1 intramuscular injection of 40 micrograms HB-Vax and 3 subsequent injections of thymopentin. After 1 month, the patients were boostered with 40 micrograms HB-Vax. There was no significant difference in T cell and monocyte function after administration of thymopentin, as determined in vitro. After 3 months, 3 patients in the placebo and 2 patients in the thymopentin group had antibody titers greater than 10 U/l. In both groups only patients with normal or slightly impaired monocyte function responded to vaccination. Thus, we were not able to demonstrate a beneficial effect of thymopentin on hepatitis B vaccination in nonresponders on chronic hemodialysis. Furthermore, functional tests were not able to identify a subpopulation of uremic nonresponders who would benefit from thymopentin.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / pharmacology
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Hepatitis B / prevention & control*
  • Hepatitis B Antibodies / biosynthesis
  • Humans
  • Male
  • Middle Aged
  • Monocytes / drug effects
  • Monocytes / immunology
  • Peptide Fragments / pharmacology*
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Renal Dialysis*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology
  • Thymopentin
  • Thymopoietins / pharmacology*
  • Thymus Hormones / pharmacology*
  • Viral Hepatitis Vaccines / immunology*
  • Viral Hepatitis Vaccines / therapeutic use

Substances

  • Adjuvants, Immunologic
  • Hepatitis B Antibodies
  • Peptide Fragments
  • Thymopoietins
  • Thymus Hormones
  • Viral Hepatitis Vaccines
  • Thymopentin