Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease

Parasit Vectors. 2011 Sep 27;4:186. doi: 10.1186/1756-3305-4-186.

Abstract

Helminth infection may modulate the expression of Toll like receptors (TLR) in dendritic cells (DCs) and modify the responsiveness of DCs to TLR ligands. This may regulate aberrant intestinal inflammation in humans with helminthes and may thus help alleviate inflammation associated with human inflammatory bowel disease (IBD). Epidemiological and experimental data provide further evidence that reducing helminth infections increases the incidence rate of such autoimmune diseases. Fine control of inflammation in the TLR pathway is highly desirable for effective host defense. Thus, the use of antagonists of TLR-signaling and agonists of their negative regulators from helminths or helminth products should be considered for the treatment of IBD.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Helminth Proteins / immunology
  • Helminth Proteins / therapeutic use*
  • Helminthiasis / immunology
  • Helminthiasis / parasitology
  • Helminths / immunology*
  • Helminths / physiology
  • Humans
  • Inflammatory Bowel Diseases / drug therapy*
  • Inflammatory Bowel Diseases / immunology*
  • Inflammatory Bowel Diseases / parasitology
  • Signal Transduction
  • Toll-Like Receptors / immunology*

Substances

  • Helminth Proteins
  • Toll-Like Receptors