Persistent corneal ulcers. What to do when ulcers won't heal

Vet Clin North Am Small Anim Pract. 1990 May;20(3):627-42. doi: 10.1016/s0195-5616(90)50054-6.


Persistent corneal erosions may be primary or secondary to a variety of ocular diseases such as KCS, infection, or adnexal disease. Primary corneal diseases that may result in nonhealing erosions include corneal EBMD and endothelial dystrophy or degeneration. The challenge that the practitioner faces is to differentiate between them and to apply the appropriate treatment. A variety of medical and surgical therapies are at the disposal of the practitioner. These include debridement, contact lens placement, superficial keratectomy, punctate keratotomy, hyperosmotic solutions, and several new drug modalities such as epidermal growth factor, fibronectin, and aprotinin.

Publication types

  • Review

MeSH terms

  • Animals
  • Combined Modality Therapy
  • Corneal Ulcer / etiology
  • Corneal Ulcer / therapy
  • Corneal Ulcer / veterinary*
  • Dog Diseases / etiology
  • Dog Diseases / therapy*
  • Dogs
  • Eye Diseases / complications
  • Eye Diseases / veterinary*
  • Wound Healing