Epidemiology and role of nonsteroidal antiinflammatory drugs in causing gastrointestinal bleeding

Gastrointest Endosc Clin N Am. 2011 Oct;21(4):597-612. doi: 10.1016/j.giec.2011.07.003.

Abstract

This article outlines the epidemiology and role of nonsteroidal antiinflammatory drugs (NSAIDs) in causing gastrointestinal (GI) bleeding. The morbidity and mortality associated with NSAID-induced GI bleeding are discussed, and the mechanisms of NSAID-related GI injury, the potency of various NSAIDs, new NSAIDs associated with a decrease in GI pathology, dual-acting antiinflammatory drugs, hydrogen sulfide-releasing NSAIDs, lipoxygenase/cyclooxygenase, phospholipid NSAIDs, and the comprehensive effects of NSAIDs on the GI tract are described.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Cyclooxygenase Inhibitors / adverse effects
  • Cyclooxygenase Inhibitors / pharmacology
  • Gastrointestinal Hemorrhage / chemically induced*
  • Gastrointestinal Hemorrhage / epidemiology*
  • Humans

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cyclooxygenase Inhibitors